Preheat and prep: Heat the oven to 350°F (175°C). Line a sheet pan with foil and place a wire rack on top, or use a loaf pan lined with parchment for easy removal.
Make the panade: In a large bowl, combine the breadcrumbs and milk. Stir and let it sit for 3–4 minutes until softened.
This keeps the meatloaf tender.
Cook the aromatics: In a small skillet over medium heat, warm a teaspoon of oil. Sauté the diced onion with a pinch of salt for 5–6 minutes until soft and lightly golden. Add the minced garlic and cook 30 seconds more.
Let cool slightly.
Mix the glaze: In a small bowl, whisk 1/2 cup BBQ sauce, ketchup, brown sugar, and Dijon mustard. Set aside for brushing.
Season the meat: To the panade, add the sautéed onion and garlic, eggs, Worcestershire, smoked paprika, onion powder, garlic powder, salt, pepper, and the remaining 1/2 cup BBQ sauce. Stir to combine.
Add the beef: Add the ground beef and gently mix with your hands or a spatula until just combined. Do not overmix or the loaf can turn dense.
Shape the loaf: Transfer the mixture to the prepared rack or loaf pan.
If free-forming, shape into a 9x5-inch loaf with slightly tapered ends. Smooth the top.
First bake: Bake for 35 minutes. Remove from the oven and brush the top and sides generously with the glaze.
Finish baking: Return to the oven and bake another 20–30 minutes, until an instant-read thermometer in the center registers 160°F (71°C).
Brush with more glaze during the final 10 minutes if you like it extra saucy.
Rest and serve: Let the meatloaf rest for 10–15 minutes before slicing. Garnish with chopped parsley and serve with extra BBQ sauce on the side.